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KMID : 0378120030300010059
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Chungnam Medical Journal
2003 Volume.30 No. 1 p.59 ~ p.68
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Expression Pattern of the Autoantibody and Effect of the Steroid Therapy in Autoimmune Hepatitis
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Park Ki-Oh
Chae Kyung-Hoon
Heo Won-Seok
Kang Yoon-Sae
Jung Jae-Hoon
Kim Yeon-Soo
Moon Hee-Seok
Lee Eaum-Seok
Kim Sun-Moon
Lee Byung-Seok
Kim Nam-Jae
Lee Heon-Young
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Abstract
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Although autoimmune hepatitis(AIH) is common in western contries, some studties have been reported in Korea. The aim of the study was to analyze the clinical and histological features and expression pattern of the autoantibody and to examine clinical course of AIH in Korea. For 9 patients diagnosed as having AIH in our hospital since 1996, we reviewed medical records and analyzed clinical and laboratory findings retrospectively. They had a probable or definite AIH according to the revised criteria of International AIH group. The mean age was 42.7(21∼68)years and 7(77.8%) were female. Three of them(33.3%) showed acute hepatitis and five of them showed cirrhosis. Fatigue and anorexia were the most frequently complained symptoms(55.6%). Four patients(44.4%) were accompanied with other autoimmune diseases. Antinuclear antibody was detected in 5(55.6%) and anti-smooth muscle antibody was detected in 7(77.8%). Three patients showed focal picemeal necrosis and four showed periportal fibrosis. Among 7 patients who received immunosuppressive therapy, six patients(85.7%) showed initial response. and biochemical and serologic remission were achived in 5(71.4%) and 3(42.8%) patients, AIH seems to be partly responsible for chronic liver disease of unknown etiology in Korea. AIH should be suspected in female patients with unknown chronic liver disease of unknown etiolgy, especially accompanied with other autoimmune disease. The clinical characteristics of AIH may not be quite different from those of Western countries.
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KEYWORD
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Autoimmune Hepatitis, Autoantibody, Steroid, Azathioprine
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